Methods for surveillance of antimalarial drug efficacy

Overview

Routine monitoring of antimalarial drug efficacy is necessary to ensure effective case management and for early detection of resistance. WHO recommends that the efficacy of first- and second-line antimalarial treatments be tested at least once every 24 months at all sentinel sites. Data collected from studies conducted according to the standard protocol inform national treatment policies.

This document includes tools and materials to conduct routine therapeutic efficacy studies (TES). It is a reference for national programmes and investigators conducting routine surveillance studies to assess the efficacy of medicines that have already been registered.